NFL Week 1 Expert Picks

Expert Previews, Odds Angles, and Betting Tips

Week 1 is where the market is sharp, the public is loud, and the best value often hides in plain sight. New coaches, roster shakeups, and fresh play-calling can flip expectations quickly—especially before sportsbooks fully “calibrate” what teams really are.
If you want a single home base for matchup-driven betting insight, start here: our NFL expert picks hub is built for bettors who care about numbers, not noise.

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Football
2026-02-08 18:30
Open
Seattle Seahawks
6 PICKS
New England Patriots

How to Approach NFL Week 1 Betting Odds

Early-season lines move fast because information hits the market in waves. A key injury note, a personnel change, or a mismatch the sharps love can push a spread off a key number in hours. In Week 1, you’re not just betting teams—you’re betting how confident the market is in those teams.

Two practical rules help right away: compare prices across multiple books and pay attention to when you place your bet. If you want a simple primer on timing and grabbing the best number, this guide on line shopping and tracking movement explains the edge in plain English.

Week 1 Game Previews (Spread, Total, and Key Matchups)

Dallas Cowboys vs. Philadelphia Eagles

Philadelphia opens the season in “set the tone” mode at home, and the market is treating it that way. The spread has been strong in favor of the Eagles, and bettors are clearly pricing in a major advantage in the trenches plus a potential mismatch when Dallas has to deal with inside pressure.

This one comes down to whether Dallas can stay on schedule—avoid third-and-long, limit negative plays, and finish drives without settling. If both offenses find rhythm early, the total has a realistic path upward. If Philly controls field position, the favorite can separate.

Kansas City Chiefs vs. Los Angeles Chargers

Neutral-site openers bring extra volatility, and the market usually reacts to public money quickly. Kansas City is still priced like the team that dictates tempo, while the Chargers’ clearest path is slowing the pace and turning the game into a shorter possession battle.

If you’re betting this matchup, keep it simple: can the Chargers protect long enough to avoid the splash plays that swing spreads? And can they finish drives without giving Kansas City short fields? If the game plays slower than expected, the under becomes more attractive.

Tampa Bay Buccaneers vs. Atlanta Falcons

Tampa Bay enters Week 1 with the résumé of a team that knows how to win the division, but Atlanta’s new-look defense adds uncertainty—especially if the pass rush shows up early. The spread suggests a competitive game, and the total leans on whether Tampa keeps the pace aggressive or turns it into a control-the-clock script.

From a betting perspective, watch early-down success. If Atlanta forces second-and-8 all night, the entire board shifts: spread value tightens and totals become harder to clear. If Tampa’s red-zone efficiency travels, the favorite can justify the price.

Cincinnati Bengals vs. Cleveland Browns

Divisional openers can be ugly, and this one has the look of a trench-heavy fight. Cincinnati is priced as the stronger offense, but Cleveland’s best chance is to win up front and make every Burrow drive feel expensive.

If Cleveland controls the line of scrimmage and wins field position, the spread becomes tougher to cover. The total also gets interesting if both defenses force long drives and limit explosive plays—exactly the recipe that turns a “should score” game into a grind.

Miami Dolphins vs. Indianapolis Colts

Miami’s ceiling is obvious when the pace is high and the explosive plays show up. Indy’s betting case is more methodical: sustain drives, shorten the game, and lean on red-zone execution rather than trading track-meet possessions.

Watch how quickly Miami gets into rhythm. If they hit early chunk plays, the total can climb and the moneyline pricing changes with it. If Indy dictates the tempo, the game can tilt toward a slower scoring profile.

Las Vegas Raiders vs. New England Patriots

This matchup sets up as a “who blinks first” game. New England is priced as the steadier side, but Las Vegas has enough volatility to make this uncomfortable if they create extra possessions or steal points with short fields.

The total profile leans lower unless the game gets sloppy. If the Raiders can generate pressure and force a couple of high-leverage mistakes, the underdog price becomes more live than the market suggests.

Arizona Cardinals vs. New Orleans Saints

Arizona’s offense is built to stress defenses with pace and vertical threats, while New Orleans usually prefers a physical, possession-oriented game. That clash makes this a classic totals handicap: can the Saints slow it down, or does Arizona force a faster script?

Third downs and red-zone efficiency decide the spread. If New Orleans turns possessions into long drives (even if they end in field goals), the underdog case improves and the under becomes easier to justify.

Pittsburgh Steelers vs. New York Jets

Low total, defensive expectations, and a spread that implies Pittsburgh control—this game is priced like points will be a premium. New York’s path is getting functional offense without falling behind early, because chasing points is where the matchup gets uncomfortable.

If the Jets can protect enough to avoid quick three-and-outs, the total stays in range and the game remains tight. If Pittsburgh starts fast and forces New York into obvious passing situations, the favorite and the under both gain strength.

New York Giants vs. Washington Commanders

Washington is priced like the more complete team, while the Giants are priced like they need “high-variance” offense to keep up. The key question is whether New York can survive pressure packages and win enough third downs to extend drives.

If Washington dictates field position and forces early mistakes, the spread can feel light. If the Giants hit a couple of deep shots and avoid turnovers, the cover case becomes real—especially if the game slows into a possession battle.

Carolina Panthers vs. Jacksonville Jaguars

Jacksonville enters as the cleaner offensive projection, but Carolina’s best angle is defensive disruption—limit explosive plays, win a few key matchups on the perimeter, and make Jacksonville execute long drives.

If the Jaguars run efficiently, the total has room to climb. If Carolina’s defense sets the tone and forces longer down-and-distance situations, the underdog moneyline becomes more interesting than the spread.

Tennessee Titans vs. Denver Broncos

This is one of the bigger Week 1 pricing gaps, and the handicap is straightforward: Denver is expected to pressure a rebuilding Tennessee offense and force the game onto the rookie quarterback’s shoulders.

If Denver gets up early, the game can drift toward a lower-scoring, control-oriented script—good news for under bettors. If Tennessee can hang around into the second half, the spread becomes harder to justify, but the market is clearly banking on Denver separation.

San Francisco 49ers vs. Seattle Seahawks

The market sees a tight divisional game with defense driving the profile. San Francisco’s advantage is pressure and discipline; Seattle’s case is home stability and enough defense to keep the game in the margins.

Turnovers are the swing factor. If the 49ers generate pressure without blitzing and win the hidden-yardage battle, they can cover. If Seattle avoids mistakes and forces long drives, the under keeps looking strong.

Detroit Lions vs. Green Bay Packers

These teams can score, but divisional familiarity can also compress outcomes. Green Bay’s pass-rush upgrade has clearly influenced early pricing, while Detroit is still valued as a top-tier offense that can win anywhere.

This matchup often comes down to red-zone performance and whether the underdog can stay efficient in the first half. If Detroit avoids early negative plays, their offense can keep this in a one-score window for four quarters.

Houston Texans vs. Los Angeles Rams

Los Angeles is priced as the safer side at home, but Houston’s path is simple: disrupt the quarterback, win a couple of short-field situations, and force the Rams to play from behind schedule.

If both defenses win early, the under is the cleanest angle. If the Rams’ offense finds rhythm and protects well, the favorite can justify the moneyline price and push the total toward the high end of the range.

Baltimore Ravens vs. Buffalo Bills

This is the Week 1 heavyweight game: elite quarterback play, explosive ceilings, and a total that reflects real shootout potential. The betting lens is about finishing—red-zone touchdowns, late-down conversions, and how each team responds when the other lands a haymaker.

If either defense is compromised (injuries or mismatches), the total can still be underpriced even at a high number. If both teams play more conservatively early, the spread becomes a coin-flip style handicap where one turnover can decide everything.

Minnesota Vikings vs. Chicago Bears

Divisional football plus a modest total usually means one thing: the market expects defense and field position to matter. Minnesota is priced as slightly stronger, but Chicago’s home underdog profile is the kind bettors circle in Week 1 when uncertainty is at its highest.

If Chicago’s front can pressure early and force mistakes, the underdog moneyline angle improves. If Minnesota controls pace and avoids turnovers, the spread stays in range—and the under remains attractive if the game turns into long drives and fewer possessions.

Week 1 Strategy: What Smart Bettors Prioritize

Week 1 is not the time to chase every game. It’s the time to bet selectively and stay disciplined with sizing. If you want a season-long framework that’s built around bankroll protection (and not just “pick more games”), read this NFL bankroll + futures strategy guide.

Yesterday
Knup Sports – POTD
$585
2. Sports Central
$574
3. James Anderson
$200
4. James Acker
$200
5. Dan Jones
$200
This Week
Jhon Walsh
$1,052
2. Sports Central
$1,014
3. Kyle Buchman
$979
4. Evan Lewis
$887
5. Rubi Chavez
$698
This Month
Sports Central
$3,423
2. Dan Jones
$1,916
3. Kyle Buchman
$1,458
4. Scott’s Picks
$1,343
5. Marc David
$970

And if you want more tactical breakdowns beyond Week 1—props, spreads, totals, and market psychology—browse the Betting News section and build a repeatable process, not a weekly guessing habit.

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If you’re trying to build one card for Week 1—or you’re betting every week and want more coverage—check the full pricing and packages page to see the options built for different bankroll styles.

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FAQ

Where should I compare Week 1 odds?

You’ll always get better long-term results when you compare prices across books. This sportsbooks guide is a good starting point if you’re deciding where to shop numbers.

Where do I find your NFL picks and betting angles?

Start at the NFL picks hub and work outward from there.

What matters most in Week 1 betting?

Timing, key numbers, and not overreacting to small-sample narratives. Week 1 is when discipline beats volume.

How do I avoid bad Week 1 bets?

Don’t force action, don’t ignore line movement, and don’t bet a number you wouldn’t take if it moved against you by a point.